Licorice attack germs in the mouth (oral ecology) – All the news ...

Feb 12
2

Oral ecology
Licorice attack germs in the mouth

An article published in the journal Mycoses, details the compounds of licorice root on a yeast which causes infections of the oral mucosa.

Céline Messier and Daniel Grenier of the Laval University oral Ecology Research Group announce discovering how liquorice can act on C.albicans. This yeast, present in the oral flora of 60% of adults, can benefit from a decrease in plan of the immune system or a disturbance of the oral flora to become invasive and infect the mouth. By conducting tests in vitro, two scientists have found that the glabridin and licochalcone A, synthesized in licorice root, block C.albicans growth by preventing form a biofilm and produce filaments which it invaded tissues.

At high doses, these molecules are toxic to cells of the oral mucosa. For the development of treatments, researchers therefore propose to use in conjunction with Nystatin, a drug antimycosique, also toxic at high doses. For Daniel Grenier, the combination of these three molecules would be an interesting way for diseases caused by C.albicans strains resistant to Nystatin or to reduce the toxic effects of this drug: “two molecules of licorice could be incorporated in creams or oral hygiene as mouthwash products”.

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Posted in Health by doctor health